The modifying clause who has made all the nations drink...indicates that Babylon here is the religious, mysterious Babylon, which is the Roman Catholic Church, as in Rev. 17:2-6, not the material Babylon, as in Rev. 18:2. Antichrist will destroy all religions when he breaks the covenant with Israel in the middle of the last week (seven years — Dan. 9:27; 11:31). This will be the beginning of the great tribulation (Matt. 24:21), which will last for three and a half years. Antichrist will exalt himself above all gods and force people to worship him (Dan. 8:9-11; 11:36-37; 2 Thes. 2:3-4; Rev. 13:4-6, 12, 14-15). At that time, he will destroy the religious Babylon, the apostate Roman Catholic Church (Rev. 17:16). Hence, the religious Babylon will fall at the beginning of the great tribulation, whereas the material Babylon will fall at the end of the great tribulation (Rev. 18:2).