In order to be saved from God’s judgment, the firstborn of both man and beast had to be redeemed by the passover lamb (Exo. 12:12-13). Here, in order to be sanctified to God, the firstborn of both a donkey and a man had to be redeemed with a lamb. This is because both a donkey and a man are unclean in the eyes of God and cannot be offered to God for His satisfaction (Lev. 11:1-8; 12:1-8). Hence, both a donkey and a man had to be redeemed again in sanctification. This shows that our natural life must be replaced by Christ. For both our salvation and our sanctification, we need Christ to be our Substitute (1 Pet. 3:18a; Gal. 2:20).